Xolik: finding cross-linked peptides with maximum paired scores in linear time
Identifying cross-linked peptides requires huge computing resources for exhaustively searching on all pairwise combinations of peptides in a large database. Commonly used heuristic screening strategies reduce the number of peptide pairs during the identification. However, heuristic screening criteria may ignore true findings. We propose a novel linear-time algorithm to exhaustively search all peptide pairs within an acceptable period of time.
|J. Dai*, W. Jiang*, F. Yu* and W. Yu. *Contributed equally to this work.
"Xolik: finding cross-linked peptides with maximum paired scores in linear time",
|Where to download Xolik|
Please install Python 2.7 and pandas for separately controlling FDR on intra/inter-protein PSMs.
|How to use it?|
To run Xolik, use the following commands.